CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53
The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
CARF Binds to Three Members (ARF, p53, and HDM2) of the p53 Tumor‐Suppressor Pathway
The INK4a locus (chromosome 9p21) encodes two structurally distinct tumor‐suppressor
proteins, p16INK4a and the alternative reading frame protein, ARF (p19ARF in mouse and …
proteins, p16INK4a and the alternative reading frame protein, ARF (p19ARF in mouse and …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
p53: only ARF the story
AC Lloyd - Nature Cell Biology, 2000 - nature.com
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Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2
PA Clark, S Llanos, G Peters - Oncogene, 2002 - nature.com
The small basic protein p14 ARF, encoded by one of the alternative transcripts from the
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
K Kurokawa, T Tanaka, J Kato - Oncogene, 1999 - nature.com
Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
p14ARF induces G2 cell cycle arrest in p53-and p21-deficient cells by down-regulating p34cdc2 kinase activity
G Normand, PG Hemmati, B Verdoodt… - Journal of Biological …, 2005 - ASBMB
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …