Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor

I Zachary - American Journal of Physiology-Cell Physiology, 2001 - journals.physiology.org
Vascular endothelial growth factor (VEGF) is essential for angiogenesis in health and
pathophysiology, and it is currently a major focus for drug targeting in the development of …

Vascular protection: a novel nonangiogenic cardiovascular role for vascular endothelial growth factor

I Zachary, A Mathur, S Yla-Herttuala… - … , and vascular biology, 2000 - Am Heart Assoc
There is widespread interest in the use of the angiogenic cytokine, vascular endothelial
growth factor (VEGF), for the treatment of cardiovascular disease. The main paradigm for …

Signaling pathways induced by vascular endothelial growth factor

B Larrivee, A Karsan - International journal of …, 2000 - spandidos-publications.com
Vasculogenesis and angiogenesis are the mechanisms responsible for the development of
the blood vessels. Angiogenesis refers to the formation of capillaries from pre-existing …

Vascular endothelial growth factor and angiogenesis

ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction

CK Domigan, S Ziyad… - … , thrombosis, and vascular …, 2015 - Am Heart Assoc
The past 5 years have witnessed a significant expansion in our understanding of vascular
endothelial growth factor (VEGF) signaling. In particular, the process of canonical activation …

Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine

S Ylä-Herttuala, TT Rissanen, I Vajanto… - Journal of the american …, 2007 - jacc.org
Members of the vascular endothelial growth factor (VEGF) family are among the most
powerful modulators of vascular biology. They regulate vasculogenesis, angiogenesis, and …

[HTML][HTML] Autocrine VEGF signaling is required for vascular homeostasis

S Lee, TT Chen, CL Barber, MC Jordan, J Murdock… - Cell, 2007 - cell.com
Vascular endothelial growth factor (VEGF) is essential for developmental and pathological
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF …

VEGF receptor signaling and endothelial function

S Kliche, J Waltenberger - IUBMB life, 2001 - Wiley Online Library
Angiogenesis, the formation of new blood vessels from preexisting ones, is a central process
during normal development and during pathological repair. Vascular endothelial growth …

Basic science review: current insights on the biology and clinical aspects of VEGF regulation

DM Birk, J Barbato, L Mureebe… - Vascular and …, 2009 - journals.sagepub.com
Vascular endothelial growth factor (VEGF) is a key molecule that orchestrates the formation
and function of vascular networks. Impaired regulation of angiogenesis is implicated in a …

Vascular endothelial growth factor-B promotes in vivo angiogenesis

JS Silvestre, R Tamarat, TG Ebrahimian… - Circulation …, 2003 - Am Heart Assoc
Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central
regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors …