The molecular genetic investigation of cancer is rapidly evolving because of ever-improving
technology. Insights into cancer disease mechanisms are being elucidated using new …

Array comparative genomic hybridization (aCGH) provides a high-resolution and high-
throughput technique for screening of copy number variations (CNVs) within the entire …

The development of solid tumors is associated with acquisition of complex genetic
alterations, indicating that failures in the mechanisms that maintain the integrity of the …

Motivation: Recurrent DNA copy number alterations (CNA) measured with array comparative
genomic hybridization (aCGH) reveal important molecular features of human genetics and …

Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer.
In recent years a variety of studies have emerged measuring total chromosomal copy …

Array comparative genomic hybridization (array CGH) is a method used to detect segmental
DNA copy number alterations. Recently, advances in this technology have enabled high …

Array comparative genomic hybridization (CGH) is being widely used to screen for recurrent
genomic copy number alterations in neoplasms, with imbalances typically detected through …

Accurate estimation of DNA copy numbers from array comparative genomic hybridization
(CGH) data is important for characterizing the cancer genome. An important part of this …

Motivation: Comparative genomic hybridization array experiments that investigate gene
copy number changes present new challenges for statistical analysis and call for methods …

Cancer progression is often driven by an accumulation of genetic changes but also
accompanied by increasing genomic instability. These processes lead to a complicated …