Background Array comparative genomic hybridization (aCGH) is a popular technique for
detection of genomic copy number imbalances. These play a critical role in the onset of …

The progression and clonal development of tumors often involve amplifications and
deletions of genomic DNA. Estimation of allele-specific copy number, which quantifies the …

The majority of human cancers as well as many developmental abnormalities harbour
chromosomal imbalances, many of which result in the gain and/or loss of genomic material …

Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor
progression. Many studies have shown that copy-number abnormalities at the DNA level are …

Background Most approaches used to find recurrent or differential DNA Copy Number
Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of …

Submicroscopic changes in chromosomal DNA copy number dosage are common and have
been implicated in many heritable diseases and cancers. Recent high-throughput …

Alterations in the genome that lead to changes in DNA sequence copy number are a
characteristic of solid tumors and are found in association with developmental abnormalities …

Abstract Microarray-based Comparative Genomic Hybridization (array-CGH) has been
applied for a decade to screen for submicroscopic DNA gains and losses in tumor and …

Array-based comparative genomic hybridization (aCGH) is a molecular cytogenetic
technique used in detecting and mapping DNA copy number alterations. aCGH is able to …

Background Microarray-based comparative genomic hybridisation (array CGH) is a
technique by which variation in relative copy numbers between two genomes can be …