A fundamental question is how proliferation and growth are timed during embryogenesis.
Although it has been suggested that the cell cycle could be a timer, the underlying …

How time is measured is an enduring issue in developmental biology. Classical models of
somitogenesis and limb development implicated intrinsic cell cycle clocks, but their …

Sonic hedgehog (Shh) signalling controls integrated specification of digit pattern and growth
in the chick wing but downstream gene networks remain to be unravelled. We analysed 3D …

Sonic Hedgehog (Shh) signaling by the polarizing region, at the posterior of the vertebrate
limb bud, is pivotal in determining digit number and identity. Shh establishes a gradient of …

It has been proposed that digit identity in chick limb bud is specified in a dose-dependent
fashion by a long-range morphogen, produced by the polarising region. One candidate is …

Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal
integration, is a paradigm for" morphogen" function, yet how Shh instructs distinct digit …

In an influential model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in
the chick wing bud specifies cells with three antero-posterior positional values, which give …

Temporal control can be considered the fourth dimension in embryonic development. The
identification of the somitogenesis molecular clock provided new insight into how embryonic …

In the classical model of chick wing digit-patterning, the polarizing region—a group of cells
at the posterior margin of the early bud—produces a morphogen gradient, now known to be …

Sonic hedgehog (Shh) signaling is essential for the anterior-posterior (AP) patterning of the
embryonic limb bud. An additional role for Shh has now been identified in the mouse and …