Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma
Y Chen, Y Zhou, S Qiu, K Wang, S Liu, XX Peng, J Li… - Cancer Letters, 2010 - Elsevier
The identification and characterization of tumor-associated antigens (TAAs) and their use in
antigen mini-arrays for cancer immunodiagnosis has been of interest recently as an …
antigen mini-arrays for cancer immunodiagnosis has been of interest recently as an …
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
RH Vonderheide, WC Hahn, JL Schultze, LM Nadler - Immunity, 1999 - cell.com
The discovery of tumor-associated antigens (TAA) in certain human malignancies has
prompted renewed efforts to develop antigen-specific immunotherapy of cancer. However …
prompted renewed efforts to develop antigen-specific immunotherapy of cancer. However …
Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model
A Morales-Kastresana, MF Sanmamed… - Clinical Cancer …, 2013 - AACR
Abstract Purpose: Immunostimulatory monoclonal antibodies (ISmAb) that unleash antitumor
immune responses are showing efficacy in cancer clinical trials. Anti-B7-H1 (PD-L1) …
immune responses are showing efficacy in cancer clinical trials. Anti-B7-H1 (PD-L1) …
Cancer vaccines: antigen selection strategy
Unlike traditional cancer therapies, cancer vaccines (CVs) harness a high specificity of the
host's immunity to kill tumor cells. CVs can train and bolster the patient's immune system to …
host's immunity to kill tumor cells. CVs can train and bolster the patient's immune system to …
The Spontaneous CD8+ T-Cell Response to HLA-A2-Restricted NY-ESO-1b Peptide in Hepatocellular Carcinoma Patients
XY Shang, HS Chen, HG Zhang, XW Pang, H Qiao… - Clinical cancer …, 2004 - AACR
Purpose: Hepatocellular carcinoma (HCC) can express various cancer-testis antigens
including NY-ESO-1, members of the SSX family, members of the MAGE family, SCP-1, and …
including NY-ESO-1, members of the SSX family, members of the MAGE family, SCP-1, and …
Selection of a clinical lead TCR targeting alpha-fetoprotein-positive liver cancer based on a balance of risk and benefit
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a
poor prognosis and limited therapeutic options. Alpha-fetoprotein (AFP), an established …
poor prognosis and limited therapeutic options. Alpha-fetoprotein (AFP), an established …
AFP-specific CD4+ helper T-cell responses in healthy donors and HCC patients
VN Evdokimova, Y Liu, DM Potter… - Journal of …, 2007 - journals.lww.com
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and is often
diagnosed at an advanced stage. We have investigated α-fetoprotein (AFP) as a tumor …
diagnosed at an advanced stage. We have investigated α-fetoprotein (AFP) as a tumor …
[PDF][PDF] Tuning T‐Cell Receptor Affinity to Optimize Clinical Risk‐Benefit When Targeting Alpha‐Fetoprotein–Positive Liver Cancer
RY Docta, T Ferronha, JP Sanderson… - …, 2019 - Wiley Online Library
Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic
options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an …
options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an …
Defining Promiscuous MHC Class II Helper T-Cell Epitopes for the HER2/neu Tumor Antigen
H Kobayashi, M Wood, Y Song, E Appella, E Celis - Cancer research, 2000 - AACR
It is accepted that both helper and CTLs play a critical role in immune antitumor responses.
Thus, the design of effective immune-based therapies for cancer relies in the identification of …
Thus, the design of effective immune-based therapies for cancer relies in the identification of …
TANTIGEN: a comprehensive database of tumor T cell antigens
Tumor T cell antigens are both diagnostically and therapeutically valuable molecules. A
large number of new peptides are examined as potential tumor epitopes each year, yet there …
large number of new peptides are examined as potential tumor epitopes each year, yet there …