The antigens epithelial cell adhesion molecule (Ep-CAM), her-2/neu, and carcinoembryonic
antigen (CEA) are potential T-cell targets in antigen-specific vaccination-based cancer …

Purpose: Immunotherapy for hepatocellular carcinoma (HCC) shows considerable promise
in improving clinical outcomes. HepaVac-101 represents a single-arm, first-in-human phase …

CD4+ T cells play critical roles in initiating, regulating, and maintaining antitumor
immuneresponses. One way to improve current tumor vaccines that mainly induce CTLs …

Purpose: To evaluate CD4+ helper functions and antitumor effect of promiscuous universal
cancer peptides (UCP) derived from telomerase reverse transcriptase (TERT). Experimental …

The recent characterization of MHC-displayed tumor-associated antigensthat recognize
effector cells of the immune system has created new perspectives for cancer therapy …

Although high frequencies of T lymphocytes specific for certain tumor-associated antigens
have been detected in some cancer patients, increasing evidence suggests that these T …

Understanding the basis of a successful clinical response after treatment with therapeutic
cancer vaccines is essential for the development of more efficacious therapy. After …

Toward the development of a novel cancer immunotherapy, we have previously identified
several tumor‐associated antigens (TAAs) and the epitopes recognized by human …

FATE and TPTE genes were originally reported to be specifically expressed in the adult
testis. We searched for the databases of Unigene and serial analysis of gene expression …

Purpose: To investigate the presence and impact of spontaneous telomerase-specific CD4 T-
cell responses in cancer patients. Experimental Design: A multistep approach was used to …