Purpose: To investigate the presence and impact of spontaneous telomerase-specific CD4 T-
cell responses in cancer patients. Experimental Design: A multistep approach was used to …

FATE and TPTE genes were originally reported to be specifically expressed in the adult
testis. We searched for the databases of Unigene and serial analysis of gene expression …

Tumor-associated human telomerase reverse transcriptase (hTERT) is expressed in> 85%
of human tumors but not in most normal cells. As a result, this antigen has received …

For investigating the expression of cancer/testis (CT) antigens in patients with hepatocellular
carcinoma (HCC) in China, and evaluating the correlations between the expression of these …

Peptide-pulsed T2 cells are routinely used to study T-cell activation by MHC-restricted
peptides derived from tumor-associated antigens (TAAs). Nevertheless, the capacity of T2 …

Recent studies suggest that immunotherapy targeting specific tumor-associated antigens
(TAAs) may be beneficial in cancer patients. However, most of these TAAs are tumor type …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a poor
prognosis and one for which immunotherapy remains a viable option. Experimental tumor …

Human telomerase reverse transcriptase (hTERT) is overexpressed in most human tumors,
making it a potential target for cancer immunotherapy. hTERT-derived CTL epitopes have …

Immunotherapy has ushered in a new era of cancer therapy, and this is also applicable to
therapy of hepatocellular carcinoma (HCC). In this context, effective development of …

The high rate of mortality and frequent incidence of recurrence associated with
hepatocellular carcinoma (HCC) reveal the need for new therapeutic approaches. In this …