Expression of human complement receptor 2 (CR2, CD21) in Cr2−/− mice restores humoral immune function
KJ Marchbank, CC Watson, DF Ritsema… - The Journal of …, 2000 - journals.aai.org
Abstract Complement receptor type 2 (CR2, CD21) is expressed by both human and murine
B cells and has been demonstrated to play a pivotal role in the humoral immune response …
B cells and has been demonstrated to play a pivotal role in the humoral immune response …
Novel roles for murine complement receptors type 1 and 2: II. Expression and function of CR1/2 on murine mesenteric lymph node T cells
In mice CR1 and CR2 are encoded at a single locus and the two alternatively spliced RNA
transcripts of the CD21 gene generate murine CR1 and CR2 (CR1/2). While the function of …
transcripts of the CD21 gene generate murine CR1 and CR2 (CR1/2). While the function of …
Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists
L Kulik, K Chen, BT Huber, VM Holers - Molecular Immunology, 2011 - Elsevier
We found that transgenic (tg) mice stably expressing a bacterial artificial chromosome (BAC)-
derived human complement receptor type 2 (CR2/CD21) gene demonstrate B cell specific …
derived human complement receptor type 2 (CR2/CD21) gene demonstrate B cell specific …
Complement receptor type 1 (CR1, CD35) expression on peripheral T lymphocytes: both CD4-and CD8-positive cells express CR1
A Rødgaard, L Dalh Christensen… - Complement and …, 1991 - karger.com
T lymphocytes from 42 healthy blood donors were examined for expression of CR1 on the
cell surface using a fluorescence-activated cell sorter. The fraction of CR1-positive T …
cell surface using a fluorescence-activated cell sorter. The fraction of CR1-positive T …
Expression of human complement receptor type 2 (CD21) in mice during early B cell development results in a reduction in mature B cells and …
KJ Marchbank, L Kulik, MG Gipson… - The Journal of …, 2002 - journals.aai.org
Abstract Complement receptor (CR) type 2 (CR2/CD21) is normally expressed only during
the immature and mature stages of B cell development. In association with CD19, CR2 plays …
the immature and mature stages of B cell development. In association with CD19, CR2 plays …
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.
H Molina, VM Holers, B Li, Y Fung… - Proceedings of the …, 1996 - National Acad Sciences
Complement receptor 1 (CR1, CD35) and complement receptor 2 (CR2, CD21) have been
implicated as regulators of B-cell activation. We explored the role of these receptors in the …
implicated as regulators of B-cell activation. We explored the role of these receptors in the …
[PDF][PDF] Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
JM Ahearn, MB Fischer, D Croix, S Goerg, M Ma, J Xia… - Immunity, 1996 - cell.com
Covalent attachment of activated products of the third component of complement to antigen
enhances its immunogenicity, but the mechanism is not clear. This effect is mediated by …
enhances its immunogenicity, but the mechanism is not clear. This effect is mediated by …
Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that …
JM Guthridge, K Young, MG Gipson… - The Journal of …, 2001 - journals.aai.org
Abstract Complement receptor type 2 (CR2)/CD21 is a B lymphocyte cell membrane
C3d/iC3b receptor that plays a central role in the immune response. Human CR2 is also the …
C3d/iC3b receptor that plays a central role in the immune response. Human CR2 is also the …
The complement receptor 3, CR3 (CD11b/CD18), on T lymphocytes: activation‐dependent up‐regulation and regulatory function
C Wagner, GM Hänsch, S Stegmaier… - European journal of …, 2001 - Wiley Online Library
Abstract The complement receptor 3 (CR3; CD11b/CD18) is present exclusively on
leukocytes, particularly on NK cells, monocytes and polymorphonuclear neutrophils …
leukocytes, particularly on NK cells, monocytes and polymorphonuclear neutrophils …
T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell‐cell interactions and dysregulation in a patient with systemic lupus …
E Levy, J Ambrus, L Kahl, H Molina… - Clinical & …, 1992 - Wiley Online Library
SUMMARY Complement receptor 2 (CR2, CD21), the receptor for both the C3d, g portion of
human complement component C3 and the Epstein‐Barr virus, has been recently described …
human complement component C3 and the Epstein‐Barr virus, has been recently described …
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