A-type potassium currents are important determinants of neuronal excitability. In spinal cord
dorsal horn neurons, A-type currents are modulated by extracellular signal-regulated …

Chronic neuropathic pain affects millions of individuals worldwide, is typically long-lasting,
and remains poorly treated with existing therapies. Neuropathic pain arising from peripheral …

Voltage‐gated potassium channels (Kv) are important regulators of neuronal excitability for
its role of regulating resting membrane potential and repolarization. Recent studies show …

Voltage‐gated K+ channel α subunits Kv4. 2 and Kv4. 3 are the major contributors of
somatodendritic A‐type K+ currents in many CNS neurons. A recent hypothesis suggests …

A-type K+ channels (A-channels) are crucial in controlling neuronal excitability, and their
downregulation in pain-sensing neurons may increase pain sensation. To test this …

Voltage-gated potassium (Kv) channels are critical in controlling neuronal excitability and
are involved in the induction of neuropathic pain. Therefore, Kv channels might be potential …

Kv7. x channels are a family of six transmembrane domain, single pore-loop, voltage-gated
K+ channels. Five members of the family have been identified to date, including the cardiac …

A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability
that have been mainly characterized in the central nervous system. By contrast, there is a …

The dorsal root ganglion (DRG) contains heterogeneous populations of sensory neurons
including primary nociceptive neurons and C-fibers implicated in pain signaling. Recent …

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A
frequent underlying condition of neuropathic pain is a sustained overexcitability of pain …