MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats
Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome is
a multiprotein complex, which results in the inflammatory response in early brain injury (EBI) …
a multiprotein complex, which results in the inflammatory response in early brain injury (EBI) …
[HTML][HTML] MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH
Y Cao, Y Wang, X Li, X Yang, B Zeng, Z Guo - Brain Research Bulletin, 2023 - Elsevier
Neuroinflammation and white matter microstructure damage are important causes of
cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 …
cognitive impairment after subarachnoid hemorrhage (SAH). Nod-like receptor protein 3 …
MCC950, the selective inhibitor of nucleotide oligomerization domain-like receptor protein-3 inflammasome, protects mice against traumatic brain injury
Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …
Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke
Activation of the NOD-like receptor protein (NLRP3)-inflammasome has been postulated to
mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury …
mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury …
Selective NLRP3 (pyrin domain–containing protein 3) inflammasome inhibitor reduces brain injury after intracerebral hemorrhage
H Ren, Y Kong, Z Liu, D Zang, X Yang, K Wood, M Li… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Intracerebral hemorrhage (ICH) is a devastating disease without
effective treatment. As a key component of the innate immune system, the NOD-like receptor …
effective treatment. As a key component of the innate immune system, the NOD-like receptor …
A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
R Kuwar, A Rolfe, L Di, H Xu, L He, Y Jiang… - Journal of …, 2019 - Springer
Background Neuroinflammation is an essential player in many neurological diseases
including traumatic brain injury (TBI). Recent studies have identified that inflammasome …
including traumatic brain injury (TBI). Recent studies have identified that inflammasome …
Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion
H Wang, H Chen, J Jin, Q Liu, D Zhong, G Li - Life sciences, 2020 - Elsevier
Aims Brain edema is a common threat to life in ischaemic brain injury. The NLRP3
inflammasome promotes the inflammatory injury after ischaemic stroke. Previous studies …
inflammasome promotes the inflammatory injury after ischaemic stroke. Previous studies …
INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats
X Hu, J Yan, L Huang, C Araujo, J Peng, L Gao… - Brain, behavior, and …, 2021 - Elsevier
Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …
RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage
K Zhou, L Shi, Z Wang, J Zhou, A Manaenko… - Experimental …, 2017 - Elsevier
The NLRP3 inflammasome functions as a crucial component of the inflammatory response
in early brain injury (EBI) after subarachnoid hemorrhage (SAH). However, the mechanisms …
in early brain injury (EBI) after subarachnoid hemorrhage (SAH). However, the mechanisms …
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