The Notch signalling pathway is one of the main regulators of endothelial biology. In the last
20 years the critical function of Notch has been uncovered in the context of angiogenesis …

Blood vessels are central to numerous vital processes during development, homeostasis
and disease. They arise from complex developmental processes that culminate in the …

The Notch proteins encompass a family of transmembrane receptors that have been highly
conserved through evolution as mediators of cell fate, and are comprised of 4 members in …

Formation of a functional blood vessel network is a complex process tightly controlled by pro-
and antiangiogenic signals released within the local microenvironment or delivered through …

Blood vessels respond to injury through a healing process that includes neointimal
hyperplasia. The vascular endothelium is a monolayer of cells that separates the outer …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Notch signaling plays many important roles in homeostasis and remodeling in the vessel
wall, and serves a critical role in the communication between endothelial cells and smooth …