Biological factors underlying sex differences in neurological disorders

H Loke, V Harley, J Lee - The international journal of biochemistry & cell …, 2015 - Elsevier
The prevalence, age of onset, pathophysiology, and symptomatology of many neurological
and neuropsychiatric conditions differ significantly between males and females. Females …

[HTML][HTML] Sex: a significant risk factor for neurodevelopmental and neurodegenerative disorders

P Pinares-Garcia, M Stratikopoulos, A Zagato, H Loke… - Brain sciences, 2018 - mdpi.com
Males and females sometimes significantly differ in their propensity to develop neurological
disorders. Females suffer more from mood disorders such as depression and anxiety …

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

VS Ratnu, MR Emami, TW Bredy - Journal of neuroscience …, 2017 - Wiley Online Library
There are inherent biological differences between males and females that contribute to sex
differences in brain function and to many sex‐specific illnesses and disorders. Traditionally …

[HTML][HTML] The role of the Y chromosome in brain function

E Kopsida, E Stergiakouli, PM Lynn… - Open …, 2009 - ncbi.nlm.nih.gov
In mammals, sex differences are evident in many aspects of brain development, brain
function and behaviour. Ultimately, such differences must arise from the differential sex …

The genetics of sex differences in brain and behavior

TC Ngun, N Ghahramani, FJ Sánchez… - Frontiers in …, 2011 - Elsevier
Biological differences between men and women contribute to many sex-specific illnesses
and disorders. Historically, it was argued that such differences were largely, if not …

[HTML][HTML] Genetics and Epigenetics of the X and Y Chromosomes in the Sexual Differentiation of the Brain

LE Cabrera Zapata, LM Garcia-Segura… - International Journal of …, 2022 - mdpi.com
For many decades to date, neuroendocrinologists have delved into the key contribution of
gonadal hormones to the generation of sex differences in the developing brain and the …

Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson's disease

J Lee, P Pinares-Garcia, H Loke… - Proceedings of the …, 2019 - National Acad Sciences
Parkinson's disease (PD) is a debilitating neurodegenerative disorder caused by the loss of
midbrain dopamine (DA) neurons. While the cause of DA cell loss in PD is unknown, male …

It is not all hormones: alternative explanations for sexual differentiation of the brain

W Davies, LS Wilkinson - Brain research, 2006 - Elsevier
Males and females of many species differ with regard to neurodevelopment, ongoing brain
function and behavior. For many years, it was assumed that these differences primarily …

Genetics, sex, and gender

C Reale, F Invernizzi, C Panteghini… - Journal of …, 2023 - Wiley Online Library
This review aims to give an overview of what has been discovered so far and what still
needs to be analyzed about how sex and gender affect the disease development. These two …

[HTML][HTML] Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology

MS Lafta, J Mwinyi, O Affatato, G Rukh… - Frontiers in …, 2024 - frontiersin.org
Increased knowledge about sex differences is important for development of individualized
treatments against many diseases as well as understanding behavioral and pathological …