Mutations in the lamin A/C gene are involved in multiple human disorders for which the
pathophysiological mechanisms are partially understood. Conflicting results prevail …

We have applied the fluorescence loss of intensity after photobleaching (FLIP) technique to
study the molecular dynamics and organization of nuclear lamin proteins in cell lines stably …

Background Recent interest in the function of the nuclear lamina has been provoked by the
discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood …

Lamins are the major components of the nuclear lamina, a network located between inner
nuclear membrane and chromatin, which plays a fundamental role in the organization of the …

Just at the beginning of the millennium the neologism laminopathies has been introduced in
the scientific vocabulary. An exponential increase of interest on the subject started …

Nuclear lamins form a fibrous nucleoskeletal network of intermediate‐sized filaments that
underlies the inner nuclear membrane. It associates with this membrane through …

Most inherited diseases are associated with mutations in a specific gene. Sometimes,
mutations in two or more different genes result in diseases with a similar phenotype. Rarely …

Mutations in LMNA, the gene that encodes nuclear lamins A and C, cause up to eight
different diseases collectively referred to as “laminopathies.” These diseases affect striated …

Most inherited diseases are associated with mutations in a specific gene. Often, mutations in
two or more different genes result in diseases with a similar phenotype. Rarely do different …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …