Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's,
Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of …

Brain iron dyshomeostasis disrupts various critical cellular functions, and age‐related iron
accumulation may contribute to deficient neurotransmission and cell death. While recent …

All cells in organisms ranging from yeast to humans utilize iron as a cofactor or structural
element of proteins that function in diverse and critical cellular functions. However …

Proper functioning of all organs, including the brain, requires iron. It is present in different
forms in biological fluids, and alterations in its distribution can induce oxidative stress and …

Over the last decades, studies from our laboratory and other groups using animal models
have shown that iron overload, resulting in iron accumulation in the brain, produces …

The redox properties that make iron an essential nutrient also make iron an efficient pro-
oxidant. Given this nascent cytotoxicity, iron homeostasis relies on a combination of iron …

Iron is a trace element of considerable interest to both chemistry and biology. In a biological
context its chemistry is vital to the roles it performs. However, that same chemistry can …

Dysregulation of iron metabolism has been observed in patients with neurodegenerative
diseases (NDs). Utilization of several importers and exporters for iron transport in brain cells …

Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins
or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to …

Iron homeostasis disruption has increasingly been implicated in various neurological
disorders. In this review, we present an overview of our current understanding of iron …