Currently, we still lack effective measures to modify disease progression in
neurodegenerative diseases. Iron-containing proteins play an essential role in many …

Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …

Iron and copper are important co-factors for a number of enzymes in the brain, including
enzymes involved in neurotransmitter synthesis and myelin formation. Both shortage and an …

As we age, brain iron homeostasis and regulation can be disrupted, making us more
vulnerable to a range of neurodegenerative diseases. Neuroimaging methods show …

Intracellular iron is essential for many neurobiological mechanisms. However, at high
concentrations, iron may induce oxidative stress and inflammation. Brain iron overload has …

Iron is a critical component of the CNS that must be tightly regulated; too little iron can result
in energy insufficiency and too much iron can result in oxidative stress. The intracellular iron …

Accumulation of iron (Fe) is often detected in the brains of people suffering from
neurodegenerative diseases. High Fe concentrations have been consistently observed in …

Aims Adult hippocampal neurogenesis is an important player in brain homeostasis and its
impairment participates in neurological diseases. Iron overload has emerged as an …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …