Iron metabolism in aging and age-related diseases
Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …
biological processes. Aging refers to the natural life process in which the physiological …
Handling iron in restorative neuroscience
The transition metal iron exerts essential roles in the central nervous system (CNS) for
oxygen transport, myelin formation, and synthesis of neurotransmitters. Being redox active …
oxygen transport, myelin formation, and synthesis of neurotransmitters. Being redox active …
Noxious iron–calcium connections in neurodegeneration
MT Núñez, C Hidalgo - Frontiers in Neuroscience, 2019 - frontiersin.org
Iron and calcium share the common feature of being essential for normal neuronal function.
Iron is required for mitochondrial function, synaptic plasticity, and the development of …
Iron is required for mitochondrial function, synaptic plasticity, and the development of …
Iron metabolism in oligodendrocytes and astrocytes, implications for myelination and remyelination
Iron is a key nutrient for normal central nervous system (CNS) development and function;
thus, iron deficiency as well as iron excess may result in harmful effects in the CNS …
thus, iron deficiency as well as iron excess may result in harmful effects in the CNS …
Iron in neurodegenerative disorders: being in the wrong place at the wrong time?
S Apostolakis, AM Kypraiou - Reviews in the Neurosciences, 2017 - degruyter.com
Brain iron deposits have been reported consistently in imaging and histologic examinations
of patients with neurodegenerative disorders. While the origins of this finding have not been …
of patients with neurodegenerative disorders. While the origins of this finding have not been …
Are essential trace elements effective in modulation of mental disorders? Update and perspectives
M Shayganfard - Biological Trace Element Research, 2022 - Springer
The emergence of mental disorders is associated with several risk factors including genetic
and environmental susceptibility. A group of nutrients serves an especially important role in …
and environmental susceptibility. A group of nutrients serves an especially important role in …
Inflaming the brain with iron
Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
The role of iron overload in diabetic cognitive impairment: A review
JR An, QF Wang, GY Sun, JN Su, JT Liu… - Diabetes, Metabolic …, 2023 - Taylor & Francis
It is well documented that diabetes mellitus (DM) is strongly associated with cognitive
decline and structural damage to the brain. Cognitive deficits appear early in DM and …
decline and structural damage to the brain. Cognitive deficits appear early in DM and …
The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders
BX Wong, JA Duce - Frontiers in pharmacology, 2014 - frontiersin.org
As with most bioavailable transition metals, iron is essential for many metabolic processes
required by the cell but when left unregulated is implicated as a potent source of reactive …
required by the cell but when left unregulated is implicated as a potent source of reactive …
Higher striatal iron concentration is linked to frontostriatal underactivation and poorer memory in normal aging
G Kalpouzos, B Garzón, R Sitnikov, C Heiland… - Cerebral …, 2017 - academic.oup.com
In the brain, intracellular iron is essential for cellular metabolism. However, an overload of
free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal …
free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal …