Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

The transition metal iron exerts essential roles in the central nervous system (CNS) for
oxygen transport, myelin formation, and synthesis of neurotransmitters. Being redox active …

Iron and calcium share the common feature of being essential for normal neuronal function.
Iron is required for mitochondrial function, synaptic plasticity, and the development of …

Iron is a key nutrient for normal central nervous system (CNS) development and function;
thus, iron deficiency as well as iron excess may result in harmful effects in the CNS …

Brain iron deposits have been reported consistently in imaging and histologic examinations
of patients with neurodegenerative disorders. While the origins of this finding have not been …

The emergence of mental disorders is associated with several risk factors including genetic
and environmental susceptibility. A group of nutrients serves an especially important role in …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

It is well documented that diabetes mellitus (DM) is strongly associated with cognitive
decline and structural damage to the brain. Cognitive deficits appear early in DM and …

As with most bioavailable transition metals, iron is essential for many metabolic processes
required by the cell but when left unregulated is implicated as a potent source of reactive …

In the brain, intracellular iron is essential for cellular metabolism. However, an overload of
free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal …