In the post genomic era, massive genetic information of the human being accelerates the
identification of target genes for treating various diseases. A wide range of nucleic acid …

The ability to safely and precisely deliver genetic materials to target sites in complex
biological environments is vital to the success of gene therapy. Numerous viral and nonviral …

As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …

The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene
therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Considerable progress in polymeric gene delivery systems has been made over the last
several years. First generation polymers have been replaced by safer and more efficient …

Highlights•Minor modifications to polymer structure determine transfection
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …

Gene therapy provides great opportunities for treating diseases from genetic disorders,
infections and cancer. To achieve successful gene therapy, development of proper gene …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Novel biocompatible polymeric gene carriers have been examined for their potential in
treating various genetic and acquired diseases. The use of polymeric gene carriers may …