The molecular insights of bile acids homeostasis in host diseases

J Zhang, A Lyu, C Wang - Life Sciences, 2023 - Elsevier
Bile acids (BAs) function as detergents promoting nutrient absorption and as hormones
regulating nutrient metabolism. Most BAs are key regulatory factors of physiological …

[HTML][HTML] Therapeutic roles of bile acid signaling in chronic liver diseases

Y Li, LG Lu - Journal of Clinical and Translational Hepatology, 2018 - ncbi.nlm.nih.gov
Bile acids (BAs) are the major metabolic product of cholesterol, having detergent-like
activities and being responsible for absorption of lipid and lipid-soluble vitamins. In addition …

Bile acids and microbiota: multifaceted and versatile regulators of the liver–gut axis

N Grüner, J Mattner - International journal of molecular sciences, 2021 - mdpi.com
After their synthesis from cholesterol in hepatic tissues, bile acids (BAs) are secreted into the
intestinal lumen. Most BAs are subsequently re-absorbed in the terminal ileum and are …

Bile-ology: from bench to bedside

L Jin, ZP Fang, M Fan, W Huang - Journal of Zhejiang University-Science …, 2019 - Springer
Bile acids (BAs) are originally known as detergents essential for the digestion and
absorption of lipids. In recent years, extensive research has unveiled new functions of BAs …

Targeting the alternative bile acid synthetic pathway for metabolic diseases

W Jia, M Wei, C Rajani, X Zheng - Protein & cell, 2021 - academic.oup.com
The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

The potential of bile acids as biomarkers for metabolic disorders

C Yin, R Zhong, W Zhang, L Liu, L Chen… - International Journal of …, 2023 - mdpi.com
Bile acids (BAs) are well known to facilitate the absorption of dietary fat and fat-soluble
molecules. These unique steroids also function by binding to the ubiquitous cell membranes …

[HTML][HTML] Bile acids and microbes in metabolic disease

DK Sah, A Arjunan, SY Park… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Bile acids (BAs) serve as physiological detergents that enable the intestinal absorption and
transportation of nutrients, lipids and vitamins. BAs are primarily produced by humans to …

Physiological role of bile acids modified by the gut microbiome

Y Kiriyama, H Nochi - Microorganisms, 2021 - mdpi.com
Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs.
Primary BAs are conjugated with glycine and taurine in the liver and then released into the …

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

CD Fuchs, M Trauner - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

[HTML][HTML] Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease

Y Gao, J Lin, C Ye, S Guo, C Jiang - Liver Research, 2023 - Elsevier
Bile acids (BAs) play important roles in the digestion of dietary fats and molecular signal
transduction, and modulation of the BA composition usually affects the progression of …