[HTML][HTML] NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression
The key to preventing mCRPC progression is understanding how androgen-dependent PCa
cells progress to independence and modify their transcriptional repertoire accordingly. We …
cells progress to independence and modify their transcriptional repertoire accordingly. We …
[HTML][HTML] NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output
Simple Summary We earlier described the involvement of the TLK1> NEK1> ATR> Chk1
axis as a key determinant of cell cycle arrest in androgen-dependent prostate cancer (PCa) …
axis as a key determinant of cell cycle arrest in androgen-dependent prostate cancer (PCa) …
[HTML][HTML] TLK1> Nek1 Axis Promotes Nuclear Retention and Activation of YAP with Implications for Castration-Resistant Prostate Cancer
D Olatunde, A De Benedetti - Cancers, 2024 - mdpi.com
Simple Summary Treatment with ARSI results in an increased expression of the TLK1B
splice variant and consequent activation of the TLK1> NEK1> YAP axis. We now provide …
splice variant and consequent activation of the TLK1> NEK1> YAP axis. We now provide …
[HTML][HTML] YAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth
N Jiang, B Ke, K Hjort-Jensen, D Iglesias-Gato… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various
forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality …
forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality …
[HTML][HTML] Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
[HTML][HTML] YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer
The transcriptional co-activator Yes-associated protein 1 (YAP1), a key nuclear effector of
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
YAP antagonizes TEAD‐mediated AR signaling and prostate cancer growth
Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ‐
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …
The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer
Background After long-term androgen deprivation therapy, 25–30% prostate cancer (PCa)
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
[HTML][HTML] The hippo pathway in prostate cancer
O Salem, CG Hansen - Cells, 2019 - mdpi.com
Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in
men. Currently, there is no effective treatment for castration-resistant prostate cancer …
men. Currently, there is no effective treatment for castration-resistant prostate cancer …
YAP1 is involved in tumorigenic properties of prostate cancer cells
Abstract The Yes Associated Protein 1 (YAP1) is a transcriptional cofactor negatively
regulated by Hippo Pathway. The dysregulation of the pathway has been shown to have a …
regulated by Hippo Pathway. The dysregulation of the pathway has been shown to have a …