Methoxychlor and vinclozolin induce rapid changes in intercellular and intracellular signaling in liver progenitor cells

P Babica, R Zurabian, ER Kumar, R Chopra… - Toxicological …, 2016 - academic.oup.com
Methoxychlor (MXC) and vinclozolin (VIN) are well-recognized endocrine disrupting
chemicals known to alter epigenetic regulations and transgenerational inheritance; …

Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška… - Toxicology and Applied …, 2020 - Elsevier
A decline in male fertility possibly caused by environmental contaminants, namely endocrine-
disrupting chemicals (EDCs), is a topic of public concern and scientific interest. This study …

Effects of methylated chrysenes on AhR-dependent and-independent toxic events in rat liver epithelial cells

M Machala, L Švihálková-Šindlerová, K Pěnčíková… - Toxicology, 2008 - Elsevier
Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry
has been listed as possibly carcinogenic to humans. Although a major attention has been in …

Methoxychlor induces oxidative stress and impairs early embryonic development in pigs

Z Geng, Y Jin, F Quan, S Huang, S Shi, B Hu… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly
used worldwide as an insecticide against pests and mosquitoes. However, MXC is not …

Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis

KA Warner, MJ Fernstrom, RJ Ruch - Toxicological Sciences, 2003 - academic.oup.com
The inhibition of gap junctional intercellular communication (GJIC) is a common effect of
nongenotoxic carcinogens and might be a biomarker for these agents. To further test this …

In utero methoxychlor exposure increases rat fetal Leydig cell number but inhibits its function

S Liu, C Li, Y Wang, T Hong, T Song, L Li, L Ye, Q Lian… - Toxicology, 2016 - Elsevier
The objective of the present study is to determine whether in utero exposure to methoxychlor
(MXC) affects rat fetal Leydig cell number, cell size, or functions. Pregnant Sprague Dawley …

Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice

I Ali, P Damdimopoulou, U Stenius… - Toxicological …, 2012 - academic.oup.com
Estrogen-like effects of cadmium (Cd) have been reported in several animal studies, and
recent epidemiological findings suggest increased risk of hormone-dependent cancers after …

Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like'cells

L Švihálková-Šindlerová, M Machala, K Pěnčíková… - Toxicology, 2007 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) with molecular weight 278 are a group of PAHs
that are mostly not covered by the current monitoring programs, despite their relative …

Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats

AME Armenti, AM Zama, L Passantino… - Toxicology and applied …, 2008 - Elsevier
Methoxychlor (MXC) is an organochlorine pesticide with estrogenic, anti-estrogenic, and anti-
androgenic properties. To investigate whether transient developmental exposure to MXC …

Endocrine-disrupting chemicals affect Sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro

A Yawer, E Sychrová, J Raška, P Babica… - Food and Chemical …, 2022 - Elsevier
The frequencies of adverse outcomes associated with male reproductive health, including
infertility and testicular cancer, are increasing. These adverse trends are partially attributed …