Methoxychlor and vinclozolin induce rapid changes in intercellular and intracellular signaling in liver progenitor cells
P Babica, R Zurabian, ER Kumar, R Chopra… - Toxicological …, 2016 - academic.oup.com
Methoxychlor (MXC) and vinclozolin (VIN) are well-recognized endocrine disrupting
chemicals known to alter epigenetic regulations and transgenerational inheritance; …
chemicals known to alter epigenetic regulations and transgenerational inheritance; …
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells
A Yawer, E Sychrová, P Labohá, J Raška… - Toxicology and Applied …, 2020 - Elsevier
A decline in male fertility possibly caused by environmental contaminants, namely endocrine-
disrupting chemicals (EDCs), is a topic of public concern and scientific interest. This study …
disrupting chemicals (EDCs), is a topic of public concern and scientific interest. This study …
Effects of methylated chrysenes on AhR-dependent and-independent toxic events in rat liver epithelial cells
M Machala, L Švihálková-Šindlerová, K Pěnčíková… - Toxicology, 2008 - Elsevier
Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry
has been listed as possibly carcinogenic to humans. Although a major attention has been in …
has been listed as possibly carcinogenic to humans. Although a major attention has been in …
Methoxychlor induces oxidative stress and impairs early embryonic development in pigs
Z Geng, Y Jin, F Quan, S Huang, S Shi, B Hu… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Methoxychlor (MXC) is an organochlorine pesticide (OCP) that was formerly
used worldwide as an insecticide against pests and mosquitoes. However, MXC is not …
used worldwide as an insecticide against pests and mosquitoes. However, MXC is not …
Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis
KA Warner, MJ Fernstrom, RJ Ruch - Toxicological Sciences, 2003 - academic.oup.com
The inhibition of gap junctional intercellular communication (GJIC) is a common effect of
nongenotoxic carcinogens and might be a biomarker for these agents. To further test this …
nongenotoxic carcinogens and might be a biomarker for these agents. To further test this …
In utero methoxychlor exposure increases rat fetal Leydig cell number but inhibits its function
S Liu, C Li, Y Wang, T Hong, T Song, L Li, L Ye, Q Lian… - Toxicology, 2016 - Elsevier
The objective of the present study is to determine whether in utero exposure to methoxychlor
(MXC) affects rat fetal Leydig cell number, cell size, or functions. Pregnant Sprague Dawley …
(MXC) affects rat fetal Leydig cell number, cell size, or functions. Pregnant Sprague Dawley …
Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice
Estrogen-like effects of cadmium (Cd) have been reported in several animal studies, and
recent epidemiological findings suggest increased risk of hormone-dependent cancers after …
recent epidemiological findings suggest increased risk of hormone-dependent cancers after …
Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like'cells
L Švihálková-Šindlerová, M Machala, K Pěnčíková… - Toxicology, 2007 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) with molecular weight 278 are a group of PAHs
that are mostly not covered by the current monitoring programs, despite their relative …
that are mostly not covered by the current monitoring programs, despite their relative …
Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats
AME Armenti, AM Zama, L Passantino… - Toxicology and applied …, 2008 - Elsevier
Methoxychlor (MXC) is an organochlorine pesticide with estrogenic, anti-estrogenic, and anti-
androgenic properties. To investigate whether transient developmental exposure to MXC …
androgenic properties. To investigate whether transient developmental exposure to MXC …
Endocrine-disrupting chemicals affect Sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro
The frequencies of adverse outcomes associated with male reproductive health, including
infertility and testicular cancer, are increasing. These adverse trends are partially attributed …
infertility and testicular cancer, are increasing. These adverse trends are partially attributed …