Growing numbers of studies indicate that polysaccharides influence signaling events
important for brain function. It has been speculated that such polysaccharide modulation of …

Previous work found evidence that α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic
acid (AMPA)‐type glutamate receptors interact with and are functionally regulated by the …

J. Neurochem.(2008) 104, 1565–1576. Abstract Chondroitin sulfate (CS) is a major
microenvironmental molecule in the CNS, and there have been few reports about its …

Chondroitin sulfate (CS) proteoglycans (CSPG s) are the most abundant PG s of the brain
extracellular matrix (ECM). Free CS could be released during ECM degradation and exert …

The endogenous dipeptide, α-N-acetylaspartylglutamate behaves as a partial agonist of N-
methyl-d-aspartate receptors, but can also activate metabotropic glutamate receptors, with a …

Excitotoxic neuronal death is mediated primarily by the N-methyl-d-aspartate receptor. N-
methyl-d-aspartate induces two forms of excitotoxicity in CA1 pyramidal neurons of cultured …

Glutamate-induced delayed neurotoxicity has been proposed to account for the selective
loss of hippocampal pyramidal neurons after an ischemic period. We have studied the …

In the brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate
glutamatergic neurotransmission and, when intensely activated, can induce excitotoxic cell …

Glatiramer acetate (GA) is a synthetic, random, basic copolymer capable of modulating
adaptive T cell responses. In animal models of various inflammatory and degenerative …

Glutamate promotes neuronal survival during brain development and destroys neurons after
injuries in the mature brain. Glutamate antagonists are in human clinical trials aiming to …