The neurotransmitter glutamate can have both excitotoxic and protective effects on neurons.
The excitotoxic effects have been intensively studied, whereas the protective effects …

Excitatory amino acid receptor-mediated neurotoxicity (excitotoxicity) has been proposed to
contribute to neuronal loss in a wide variety of neurodegenerative conditions. Although …

Intracellular recording revealed that cytotoxic activation of excitatory amino acid receptors by
glutamate or N-methyl-d-aspartate (NMDA) elicited an extended neuronal depolarization …

Although experimental studies have widely shown that the pharmacological blockade of
ionotropic glutamate receptors reduces ischemic damage, clinical trials with classical AMPA …

The inhibition of N-acetylated α-linked acidic dipeptidase (NAALADase: glutamate
carboxypeptidase II) has been previously shown to protect against ischemic injury …

N-Acetylaspartylglutamate (NAAG) is a dipeptide, and has been demonstrated to be a
putative neurotransmitter in the brain. We hereby report the toxicity of NAAG in sagittal slices …

The antagonist pharmacology of glutamate neurotoxicity was quantitatively examined in
murine cortical cell cultures. Addition of 1-3 mM DL-2-amino-5-phosphonovalerate (APV), or …

BACKGROUND: Excitotoxicity and neuronal death following ischemia involve AMPA (α-
amino-3hydroxy-5-methylisoxazole-4-propionic acid) glutamate receptors. We have recently …

Exposure of cultured cerebellar neurons to±-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid (AMPA) in the presence of aniracetam protects all of the vulnerable …

Excitatory amino acid receptor activation and reactive oxygen species production are
important mediators of neuronal death following acute brain injury and can lead to loss of …