The excitatory and excitotoxic actions of the endogenous excitatory amino acid (EAA)
neurotransmitter, glutamate, are mediated by activation of three common subtypes of EAA …

Neuroactive steroids can modulate brain excitability by interaction with several
neurotransmitter receptor‐associated channels. These compounds may thus exert profound …

Injection of the N-methyl-d-aspartate receptor agonist, quinolinic acid, into the rat striatum in
vivo results in the degeneration of cholinergic and GABAergic neurons, as determined …

Since group II metabotropic glutamate (mGlu) receptors are a potential target for the
amelioration of neuronal injury, we evaluated the ability of group II mGlu receptor agonists to …

We demonstrate by reverse transcriptase‐polymerase chain reaction and Southern blotting
that an immortalized rat oligodendroglial cell line (CG‐4) expresses the non‐N‐methyl‐d …

Chondroitin sulphate proteoglycan (CSPG) inhibits axonal regeneration in the central
nervous system (CNS) and its local degradation promotes repair. We postulated that the …

Stimulation of group I metabotropic glutamate receptors (mGluRs) has been shown to
protect against N-methyl-d-aspartate receptor-mediated cell death, but the underlying …

Exposure of neuron-enriched cultures of the embryonic rat cerebral cortex to glutamate (Glu)
resulted in a concentration-dependent (EC50= 50μM) increase in the release of lactate …

Activation of group I metabotropic glutamate receptors (mGlu1 or‐5 receptors) is known to
either enhance or attenuate excitotoxic neuronal death depending on the experimental …

Brain injury following cerebral ischaemia (stroke) involves a complex combination of
pathological processes, including excitotoxicity and inflammation leading to necrotic and …