[HTML][HTML] The role of natural killer T cells in cancer—a phenotypical and functional approach

D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

J Cursons, F Souza-Fonseca-Guimaraes… - Cancer immunology …, 2019 - AACR
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be
linked to immunotherapy success. NK cells and other innate immune components could be …

The role of natural killer cells in tumor control—effectors and regulators of adaptive immunity

ME Wallace, MJ Smyth - Springer seminars in immunopathology, 2005 - Springer
Natural killer (NK) cells are the primary effector cells of the innate immune system and have
a well-established role in tumor rejection in a variety of spontaneous and induced cancer …

[HTML][HTML] Natural killer cell interactions with myeloid derived suppressor cells in the tumor microenvironment and implications for cancer immunotherapy

C Zalfa, S Paust - Frontiers in Immunology, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …

Immature natural killer cells promote progression of triple-negative breast cancer

G Thacker, S Henry, A Nandi, R Debnath… - Science translational …, 2023 - science.org
Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor
microenvironment and are generally considered to be antitumorigenic. Using single-cell …

Natural killer cells infiltrating human nonsmall‐cell lung cancer are enriched in CD56brightCD16 cells and display an impaired capability to kill tumor cells

P Carrega, B Morandi, R Costa, G Frumento, G Forte… - Cancer, 2008 - Wiley Online Library
BACKGROUND. Despite natural killer (NK) cells being originally identified and named
because of their ability to kill tumor cells in vitro, only limited information is available on NK …

[HTML][HTML] Killers 2.0: NK cell therapies at the forefront of cancer control

JJ Hodgins, ST Khan, MM Park… - The Journal of …, 2019 - Am Soc Clin Investig
Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

[HTML][HTML] The changing role of natural killer cells in cancer metastasis

IS Chan, AJ Ewald - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Natural killer cell‐based immunotherapy in cancer: current insights and future prospects

T Sutlu, E Alici - Journal of internal medicine, 2009 - Wiley Online Library
As our understanding of the molecular mechanisms governing natural killer (NK) cell activity
increases, their potential in cancer immunotherapy is growing increasingly prominent. This …

[HTML][HTML] Discovery of specialized NK cell populations infiltrating human melanoma metastases

LF de Andrade, Y Lu, A Luoma, Y Ito, D Pan, JW Pyrdol… - Jci Insight, 2019 - ncbi.nlm.nih.gov
NK cells contribute to protective antitumor immunity, but little is known about the functional
states of NK cells in human solid tumors. To address this issue, we performed single-cell …