Natural killer cells and other innate lymphoid cells in cancer

L Chiossone, PY Dumas, M Vienne… - Nature Reviews …, 2018 - nature.com
Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

Natural killer cell-mediated immunosurveillance of human cancer

KJ Malmberg, M Carlsten, A Björklund, E Sohlberg… - Seminars in …, 2017 - Elsevier
The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …

[HTML][HTML] Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

NK and NKT cells have distinct properties and functions in cancer

X Liu, L Li, F Si, L Huang, Y Zhao, C Zhang, DF Hoft… - Oncogene, 2021 - nature.com
Natural killer (NK) and natural killer T (NKT) cells are two important cell subsets of the innate
immune system. NK and NKT cells share many phenotypes and functions for anti-tumor …

[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities

W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma

S Platonova, J Cherfils-Vicini, D Damotte, L Crozet… - Cancer research, 2011 - AACR
Both the innate and adaptive immune systems contribute to tumor immunosurveillance in
mice and humans; however, there is a paucity of direct evidence of a role for natural killer …

NK cells to cure cancer

C Di Vito, J Mikulak, E Zaghi, S Pesce… - Seminars in …, 2019 - Elsevier
Natural Killer (NK) cells are innate lymphocytes able to mediate immune-surveillance and
clearance of viral infected and tumor-transformed cells. Growing experimental and clinical …

Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells

S Paul, N Kulkarni, Shilpi, G Lal - Oncoimmunology, 2016 - Taylor & Francis
Natural killer (NK) cells are known to have effector and cytolytic properties to kill virus
infected or tumor cells spontaneously. Due to these properties, NK cells have been used as …

Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity

G Pietra, C Manzini, S Rivara, M Vitale, C Cantoni… - Cancer research, 2012 - AACR
Natural killer (NK) cells play a key role in tumor immune surveillance. However, adoptive
immunotherapy protocols using NK cells have shown limited clinical efficacy to date …

Tumor-infiltrating natural killer cells

B Cózar, M Greppi, S Carpentier, E Narni-Mancinelli… - Cancer discovery, 2021 - AACR
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …