Natural killer cells: tumor surveillance and signaling
LG Meza Guzman, N Keating, SE Nicholson - Cancers, 2020 - mdpi.com
Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …
NK cells preferentially target tumor cells with a cancer stem cell phenotype
Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to
antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are …
antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are …
Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens
RW Childs, M Carlsten - Nature reviews Drug discovery, 2015 - nature.com
Scientific insights into the human immune system have recently led to unprecedented
breakthroughs in immunotherapy. In the twenty-first century, drugs and cell-based therapies …
breakthroughs in immunotherapy. In the twenty-first century, drugs and cell-based therapies …
[PDF][PDF] High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice
A Crinier, P Milpied, B Escaliere, C Piperoglou… - Immunity, 2018 - cell.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) involved in antimicrobial and
antitumoral responses. Several NK cell subsets have been reported in humans and mice …
antitumoral responses. Several NK cell subsets have been reported in humans and mice …