Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven
human Sirtuins (SIRT1–7) that display diversity in cellular localization and function. Growing …

SIRT1 is a member of the silent information regulator 2 (Sir2a) protein family of enzymes that
is ubiquitous in terrestrial life. Following the discovery of the yeast Sir2 protein, mammalian …

The research of the last decade highlighted the existence of a family of genes activated by
cellular stresses that allow the cells to reactivate defense and repair activities regardless of …

The plant polyphenol resveratrol (3, 5, 4′-trihydroxystilbene) has been touted to have
multiple health benefits. A commonly cited mechanism of resveratrol action is via the …

Sirtuin 2 (SIRT2) has been associated to aging and age-related pathologies. Specifically, an
age-dependent accumulation of isoform 3 of SIRT2 in the CNS has been demonstrated; …

The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all
organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide …

One of the causes for aging is free radical damage. Resveratrol (RSV), a polyphenolic
compound has been shown to act as an antioxidant and anti-inflammatory. The objective …

This review summarizes the effects of resveratrol in neurodegenerative diseases and
speculates on the direction the field will take in the immediate future. In particular, we …

Members of the sirtuin family including the founding protein Sir2 in Saccharomyces
cerevisiae have been linked to lifespan extension in simple organisms. This finding …

Sirtuin1 (SIRT1), a type III protein deacetylase, is considered as a novel anti-aging protein
involved in regulation of cellular senescence/aging and inflammation. SIRT1 level and …