Background Multicellular organisms require precise gene regulation during ontogeny, and
epigenetic modifications, such as DNA methylation and histone modification, facilitate this …

The fate and function of epigenetic marks during the germline-to-embryo transition is a key
issue in developmental biology, with relevance to stem cell programming and …

Background Zygotic genome activation (ZGA) occurs at the mid-blastula transition (MBT) in
zebrafish and is a period of extensive chromatin remodeling. Genome-scale gametic …

Marked epigenetic reprogramming is essential to convert terminally differentiated gametes
to totipotent embryos. It remains puzzling why postfertilization global DNA reprogramming …

Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This
reprogramming is required for proper embryonic development and cell differentiation. In …

Genome-wide profiling of DNA methylation and histone modifications answered many
questions as to how the genes are regulated on a global scale and what their epigenetic …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To understand this process, we determined the DNA methylation (DNAme) …

DNA methylation and histone modifications are epigenetic marks implicated in the complex
regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and …

The DNA methylome is re-patterned during discrete phases of vertebrate development. In
zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …