Although it is recognized that many common complex diseases are a result of multiple
genetic and environmental risk factors, studies of gene‐environment interaction remain a …

The recent success of genome-wide association studies in finding susceptibility genes for
many common diseases presents tremendous opportunities for epidemiologic studies of …

Recently, many new approaches, study designs, and statistical and analytical methods have
emerged for studying gene-environment interactions (G× Es) in large-scale studies of …

As a result of the Human Genome Project, epidemiologists can study thousands of genes
and their interaction with the environment. The challenge is how to best present and analyze …

Genetic and environmental factors are both known to contribute to susceptibility to complex
diseases. Therefore, the study of gene-environment interaction (G× E) has been a focus of …

Studies of gene–environment interactions aim to describe how genetic and environmental
factors jointly influence the risk of developing a human disease. Gene–environment …

Case–control studies have many advantages for identifying disease-related genes, but are
limited in their ability to detect gene–environment interactions. The prospective cohort …

The lack of knowledge about the earliest events in disease development is due to the multi-
factorial nature of disease risk. This information gap is the consequence of the lack of …

A growing knowledge base of genetic and environmental information has greatly enabled
the study of disease risk factors. However, the computational complexity and statistical …

Study of gene–environment interaction is important for improving accuracy and precision in
the assessment of both genetic and environmental influences. This overview presents a …