Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

[图书][B] Antimicrobial peptides

DA Phoenix, SR Dennison, F Harris - 2012 - books.google.com
In this text, the small team of expert authors presents the field in a comprehensive and
accessible manner that is well suited for students and junior researchers. The result is a …

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

R Eckert - Future microbiology, 2011 - Future Medicine
Since the discovery of magainins, cecropins and defensins 30 years ago, antimicrobial
peptides (AMPs) have been hailed as a potential solution to the dearth of novel antibiotic …

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

U Piotrowska, M Sobczak… - Chemical Biology & Drug …, 2017 - Wiley Online Library
Micro‐organism resistance is an important challenge in modern medicine due to the global
uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMP s) …

Antimicrobial peptides: new candidates in the fight against bacterial infections

O Toke - Peptide Science: Original Research on Biomolecules, 2005 - Wiley Online Library
Antimicrobial peptides (AMPs) of innate origin are agents of the most ancient form of
defense systems. They can be found in a wide variety of species ranging from bacteria …

[HTML][HTML] Antimicrobial susceptibility testing of antimicrobial peptides to better predict efficacy

DK Mercer, MDT Torres, SS Duay, E Lovie… - Frontiers in cellular …, 2020 - frontiersin.org
During the development of antimicrobial peptides (AMP) as potential therapeutics,
antimicrobial susceptibility testing (AST) stands as an essential part of the process in …

The vast structural diversity of antimicrobial peptides

J Koehbach, DJ Craik - Trends in Pharmacological Sciences, 2019 - cell.com
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense.
They have diverse structures and target a variety of organisms, both by nonspecific …

Peptide design for antimicrobial and immunomodulatory applications

EF Haney, REW Hancock - Peptide Science, 2013 - Wiley Online Library
The increasing threat of antibiotic resistance in pathogenic bacteria and the dwindling
supply of antibiotics available to combat these infections poses a significant threat to human …

Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens

B Mishra, J Lakshmaiah Narayana… - Proceedings of the …, 2019 - National Acad Sciences
As bacterial resistance to traditional antibiotics continues to emerge, new alternatives are
urgently needed. Antimicrobial peptides (AMPs) are important candidates. However, how …

A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and …

MF Mohamed, A Brezden, H Mohammad… - Scientific Reports, 2017 - nature.com
Antimicrobial peptides (AMPs) represent a promising therapeutic alternative for the
treatment of antibiotic-resistant bacterial infections. The present study investigates the …