Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

[HTML][HTML] Multi-omics characterization of silent and productive HPV integration in cervical cancer

J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …

[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …

Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis

X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
Integration of human papilloma virus (HPV) DNA into the human genome may progressively
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …

[HTML][HTML] Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …

[HTML][HTML] Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical …

X Lu, Q Lin, M Lin, P Duan, L Ye, J Chen, X Chen… - PLoS …, 2014 - journals.plos.org
The constitutive expression of the high-risk HPV E6 and E7 viral oncogenes is the major
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer

NPD Nguyen, V Deshpande, J Luebeck… - Nucleic acids …, 2018 - academic.oup.com
The integration of viral sequences into the host genome is an important driver of
tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular …

[HTML][HTML] HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

A Warburton, CJ Redmond, KE Dooley, H Fu… - PLoS …, 2018 - journals.plos.org
Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in
HPV-associated cancers. Integration is random, and each site is unique depending on how …

[HTML][HTML] Direct comparison of HPV16 viral genomic integration, copy loss, and structural variants in oropharyngeal and uterine cervical cancers reveal distinct …

TP Schrank, S Kim, H Rehmani, A Kothari, D Wu… - Cancers, 2022 - mdpi.com
Simple Summary HPV16 causes approximately 60% of uterine cervical cancer and 95% of
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …