Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer
M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …
for the development of cervical cancer, however, the underlying mechanism of HPV …
[HTML][HTML] Multi-omics characterization of silent and productive HPV integration in cervical cancer
J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …
significant public health problem worldwide. HPV integration sites can be silent or actively …
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …
By conducting whole-genome sequencing and high-throughput viral integration detection …
[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …
Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis
X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
Integration of human papilloma virus (HPV) DNA into the human genome may progressively
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …
[HTML][HTML] Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer
L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …
[HTML][HTML] Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical …
X Lu, Q Lin, M Lin, P Duan, L Ye, J Chen, X Chen… - PLoS …, 2014 - journals.plos.org
The constitutive expression of the high-risk HPV E6 and E7 viral oncogenes is the major
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
The integration of viral sequences into the host genome is an important driver of
tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular …
tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular …
[HTML][HTML] HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression
A Warburton, CJ Redmond, KE Dooley, H Fu… - PLoS …, 2018 - journals.plos.org
Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in
HPV-associated cancers. Integration is random, and each site is unique depending on how …
HPV-associated cancers. Integration is random, and each site is unique depending on how …
[HTML][HTML] Direct comparison of HPV16 viral genomic integration, copy loss, and structural variants in oropharyngeal and uterine cervical cancers reveal distinct …
TP Schrank, S Kim, H Rehmani, A Kothari, D Wu… - Cancers, 2022 - mdpi.com
Simple Summary HPV16 causes approximately 60% of uterine cervical cancer and 95% of
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …
HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very …
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