Synthesis, characterization and in vitro biological evaluation of two matrine derivatives

X Cheng, J Ye, H He, Z Liu, C Xu, B Wu, X Xiong… - Scientific Reports, 2018 - nature.com
Matrine is a traditional Chinese medicine and botanical pesticide with broad biological
activities, including pharmacological and agricultural activities. In present work, two matrine …

Research advances on anticancer activities of matrine and its derivatives: An updated overview

H ur Rashid, Y Xu, Y Muhammad, L Wang… - European journal of …, 2019 - Elsevier
Cancer is the second leading cause of mortality, only overcome by cardiovascular diseases,
and has caused more than 8.7 million deaths in 2015 all over the world. This figure is …

Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

L Wang, Y You, S Wang, X Liu, B Liu, J Wang… - Bioorganic & medicinal …, 2012 - Elsevier
Nineteen previously unreported matrine derivatives were synthesized and characterized
using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance …

[HTML][HTML] Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry

JAH Kowah, R Gao, F Li, C Guang, M Jiang… - European Journal of …, 2023 - Elsevier
Matrine alkaloid is a type of Sophora flavescens (Ku Shen) found in plants. It holds excellent
applications for anticancer, antimicrobials, antibacterial, anti pests, and other applications in …

Matrine: Bioactivities and structural modifications

J Huang, H Xu - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen),
Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives …

Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents

Z Li, M Luo, B Cai, L Wu, M Huang, J Jiang… - Bioorganic & Medicinal …, 2018 - Elsevier
Using matrine (1) as the lead compound, a series of new 14-(N-substituted-2-
pyrrolemethylene) matrine and 14-(N-substituted-indolemethylene) matrine derivatives was …

Matrine: a promising natural product with various pharmacological activities

H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

The advances in bioactivities, mechanisms of action and structural optimizations of matrine and its derivatives

J Xu, M Lv, H Xu - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Matrine, a tetracyclo-quinolizidine alkaloid, is isolated from the industrial crop plant Sophora
flavescens. Due to a wide range of pharmacological and agricultural properties, the …

Research progress of agricultural bioactivities and structural modifications of matrine and its analogues

Z Bingchuan, XU Hui - Chinese Journal of Pesticide Science, 2019 - nyxxb.cn
Matrine and its analogues are a kind of alkaloids isolated from Sophora flavescens and
Sophora alopecuroides. They have exhibited a broad scope of medical (eg, anticancer, anti …

Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents

Y Xu, P Liang, H Rashid, L Wu, P Xie, H Wang… - Medicinal Chemistry …, 2019 - Springer
Using matrine (1) as the lead compound, a series of new piperazinyl matrine derivatives
were designed, synthesized and evaluated for their antitumor activities in vitro and in vivo …