Matrine, a Sophora alkaloid, exhibits antiproliferative and anti-carcinogenic activities
through several mechanisms. In a previous study, we found that matrine could effectively …

Matrine, one of the main active components from the dry roots of Sophora flavescence, was
known to induce apoptosis in a variety of tumor cells in vitro. However, the molecular …

Matrine is an alkaloid extracted from the leguminous plant Sophora flavescens. Matrine has
clinical effects in the treatment of tumors, including those in lung cancer, nasopharyngeal …

Background C-Myc overexpression is associated with poor prognosis and aggressive
progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the …

Lung cancer is the leading cause of cancer‑related mortality in humans. The prognosis for
advanced lung cancer patients is extremely poor. Current standard care is rather ineffective …

Matrine, a sophora alkaloid, has been demonstrated to exert antitumor effects on many types
of cancer. However, its bioactivity is weak and its potential druggability is low. We modified …

Nasopharyngeal carcinoma (NPC) frequently occurs in Southern China. The main
treatments of NPC are chemotherapy and radiotherapy. However, chemo-resistance arises …

Matrine has been used in anti-inflammatory and anticancer therapies for a long time.
However, the antimetastatic effect and molecular mechanism (s) of matrine on osteosarcoma …

Abstract A series of 1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives was
synthesized through one-pot condensation reaction; it was confirmed via NMR, FTIR, MS …

A series of novel matrine-dithiocarbamate (DTC) hybrids were efficiently synthesised from
matrine through a three-step sequence involving basic hydrolysis, esterification, and DTC …