Germinal centers (GCs) are inducible lymphoid microenvironments that support the
generation of memory B cells, affinity maturation, and isotype switching. Previously …

Upon antigen exposure, activated B cells in antigen‐draining lymphoid organs form
microanatomical structures, called germinal centers (GCs), where affinity maturation occurs …

Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal
expansion, class switch recombination, somatic hypermutation, and affinity maturation …

The germinal center (GC) reaction is a key feature of adaptive humoral immunity. GCs
represent the site where mature B cells refine their B-cell receptor (BCR) and are selected …

Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of
immunization. They arise in about 1 week and can persist for several months. In GC s, B …

The germinal center (GC) reaction in T cell dependent antibody responses is crucial for the
generation of B cell memory and plays a critical role in B cell lymphomagenesis. To gain …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

Highlights•Only high-affinity GC B cells undergo PC differentiation.•PC differentiation
initiates in the light zone via antigen contact.•Maturing PCs requires T-cell help and egress …

Highlights•High affinity GC B cells are positively selected or differentiate into plasma
cells.•Strength of stimulus in the light zone determines this decision.•Multiple fates can befall …

Germinal centers (GCs) are complex, multicell-type, transient structures that form in
secondary lymphatic tissues in response to T cell-dependent stimulation. This process is …