Significance: There are a number of redox-active anticancer agents currently in
development based on the premise that altered redox homeostasis is necessary for cancer …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

The pursuit of effective anticancer therapies has led to a burgeoning interest in the realm of
redox modulation. This review provides a comprehensive exploration of the intricate …

Significance: Cancer is related to redox biology from many points of view, such as initiation
and promotion, metabolism and growth, invasion and metastasis, vascularization, or through …

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …

Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …

Reactive oxygen species (ROS) have recently emerged as promising targets for anticancer
drug discovery. Constitutively elevated levels of cellular oxidative stress and dependence on …

Redox balance underlies cellular homeostasis. Cancer initiation and progression has been
linked to the disruption of redox balance and oxidative stress. Recent findings exemplify the …

The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the
rational design of new anticancer agents. In addition to their well characterized effects on …

Cancer remains the second leading cause of death worldwide. Research is currently
focused on finding novel anticancer therapies and elucidating their mechanisms of action …