Objective We investigated whether dexmedetomidine provided protective effects on cecal
ligation and puncture (CLP)–induced septic mice, through suppressing the expression of pro …

Background Some studies have demonstrated dexmedetomidine has anti-inflammatory
effect on septic rats. However, the mechanism of how dexmedetomidine exerts these effects …

Dexmedetomidine has been reported to reduce mortality in septic rats. This study was
designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung …

In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries
were studied in the rat model of intra-abdominal sepsis by immunohistological and …

Previous studies have shown that dexmedetomidine exerted anti-inflammatory effect on
several animal models with inflammation, but the mechanism is not clear. This study intends …

BACKGROUND: Dexmedetomidine has already been used in septic patients as a new
sedative agent, few studies have examined its effects on immunomodulation. Therefore, the …

Traumatic brain injury (TBI) affects people in all demographics, since it is associated with a
variety of chronic degenerative diseases, such as Alzheimer's and Parkinson's disease. In …

The aim was to verify that dexmedetomidine (DEX) can attenuate CLP-induced intestinal
injury via inhibition of inflammation. Male Sprague-Dawley (SD) rats were randomly …

Dexmedetomidine (Dex) is widely used for sedation in intensive care units and can be used
as an adjunct to anesthetics. Previous studies have demonstrated that Dex has anti …

Background Since sedatives are often administered to immune-compromised and critically
ill patients, our understanding of immunomodulation by sedation will be critical …