Pharmacokinetic and pharmacodynamic responses to clopidogrel: evidences and perspectives

YJ Zhang, MP Li, J Tang, XP Chen - International Journal of …, 2017 - mdpi.com
Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in
patients with acute coronary syndrome (ACS) and in those undergoing percutaneous …

Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond

HG Xie, JJ Zou, ZY Hu, JJ Zhang, F Ye… - Pharmacology & …, 2011 - Elsevier
The widespread use of clopidogrel alone or in combination with aspirin has significantly
benefited patients with acute coronary syndrome who are managed medically or by …

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance …

AL Frelinger, DL Bhatt, RD Lee, DJ Mulford… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to determine whether known genetic, drug, dietary,
compliance, and lifestyle factors affecting clopidogrel absorption and metabolism fully …

Nonresponders to clopidogrel: pharmacokinetics and interactions involved

MA Giorgi, G Di Girolamo… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: The use of clopidogrel and aspirin has become standard therapy in
patients with acute coronary syndromes and stent implantation. However, concern arises …

Clinical pharmacokinetics and pharmacodynamics of clopidogrel

XL Jiang, S Samant, LJ Lesko, S Schmidt - Clinical pharmacokinetics, 2015 - Springer
Acute coronary syndromes (ACS) remain life-threatening disorders, which are associated
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …

The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial

P Gladding, M Webster, I Zeng, H Farrell… - JACC: Cardiovascular …, 2008 - jacc.org
Objectives: This study assessed the effect of pharmacogenetics on the antiplatelet effect of
clopidogrel. Background: Variability in clopidogrel response might be influenced by …

Determinants to optimize response to clopidogrel in acute coronary syndrome

B Giusti, AM Gori, R Marcucci, C Saracini… - Pharmacogenomics …, 2010 - Taylor & Francis
The inhibition of platelet function by antiplatelet therapy determines the improvement of the
survival of patients with clinically evident cardiovascular disease. Clopidogrel in …

Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations

KJ Ellis, GA Stouffer, HL McLeod, CR Lee - Pharmacogenomics, 2009 - Future Medicine
Antiplatelet therapy with clopidogrel is the current standard of care for coronary artery
disease patients undergoing a percutaneous coronary intervention. However, approximately …

The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility

D Tousoulis, G Siasos, M Zaromytidou… - Current medicinal …, 2011 - ingentaconnect.com
Clopidogrel, an antiplatelet agent, prevents platelet aggregation by inhibiting the adenosine
disphosphate (ADP) P2Y12 receptor, which is located on the platelet surface. Although dual …

Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring

US Tantry, PA Gurbel - Current pharmaceutical design, 2013 - ingentaconnect.com
Dual antiplatelet therapy of clopidogrel added aspirin is an established treatment strategy to
prevent recurrent ischemic event occurrence in coronary artery disease patients. Generally …