Pharmacokinetic and pharmacodynamic responses to clopidogrel: evidences and perspectives
Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in
patients with acute coronary syndrome (ACS) and in those undergoing percutaneous …
patients with acute coronary syndrome (ACS) and in those undergoing percutaneous …
Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond
HG Xie, JJ Zou, ZY Hu, JJ Zhang, F Ye… - Pharmacology & …, 2011 - Elsevier
The widespread use of clopidogrel alone or in combination with aspirin has significantly
benefited patients with acute coronary syndrome who are managed medically or by …
benefited patients with acute coronary syndrome who are managed medically or by …
Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance …
AL Frelinger, DL Bhatt, RD Lee, DJ Mulford… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to determine whether known genetic, drug, dietary,
compliance, and lifestyle factors affecting clopidogrel absorption and metabolism fully …
compliance, and lifestyle factors affecting clopidogrel absorption and metabolism fully …
Nonresponders to clopidogrel: pharmacokinetics and interactions involved
MA Giorgi, G Di Girolamo… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: The use of clopidogrel and aspirin has become standard therapy in
patients with acute coronary syndromes and stent implantation. However, concern arises …
patients with acute coronary syndromes and stent implantation. However, concern arises …
Clinical pharmacokinetics and pharmacodynamics of clopidogrel
Acute coronary syndromes (ACS) remain life-threatening disorders, which are associated
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …
The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial
P Gladding, M Webster, I Zeng, H Farrell… - JACC: Cardiovascular …, 2008 - jacc.org
Objectives: This study assessed the effect of pharmacogenetics on the antiplatelet effect of
clopidogrel. Background: Variability in clopidogrel response might be influenced by …
clopidogrel. Background: Variability in clopidogrel response might be influenced by …
Determinants to optimize response to clopidogrel in acute coronary syndrome
The inhibition of platelet function by antiplatelet therapy determines the improvement of the
survival of patients with clinically evident cardiovascular disease. Clopidogrel in …
survival of patients with clinically evident cardiovascular disease. Clopidogrel in …
Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations
Antiplatelet therapy with clopidogrel is the current standard of care for coronary artery
disease patients undergoing a percutaneous coronary intervention. However, approximately …
disease patients undergoing a percutaneous coronary intervention. However, approximately …
The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility
D Tousoulis, G Siasos, M Zaromytidou… - Current medicinal …, 2011 - ingentaconnect.com
Clopidogrel, an antiplatelet agent, prevents platelet aggregation by inhibiting the adenosine
disphosphate (ADP) P2Y12 receptor, which is located on the platelet surface. Although dual …
disphosphate (ADP) P2Y12 receptor, which is located on the platelet surface. Although dual …
Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring
US Tantry, PA Gurbel - Current pharmaceutical design, 2013 - ingentaconnect.com
Dual antiplatelet therapy of clopidogrel added aspirin is an established treatment strategy to
prevent recurrent ischemic event occurrence in coronary artery disease patients. Generally …
prevent recurrent ischemic event occurrence in coronary artery disease patients. Generally …
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