The ability of a pathogen to metabolically adapt to the local environment for optimal
expression of virulence determinants is a continued area of research. Orthologs of the …

The ability of a pathogen to evade neutrophil phagocytic killing mechanisms is critically
important for dissemination and establishment of a systemic infection. Understanding how …

As an exclusively human pathogen, Streptococcus pyogenes (the group A streptococcus
[GAS]) has specifically adapted to evade host innate immunity and survive in multiple tissue …

Summary Interleukin-8 (IL-8) promotes neutrophil-mediated host defense through its
chemoattractant and immunostimulatory activities. The Group A Streptococcus (GAS) …

The recent genome sequencing of several Streptococcus pyogenes serotype strains
allowed the design of corresponding DNA microarrays and their usage for specific …

Streptococcus iniae is a major fish pathogen that contributes to large annual losses in the
aquaculture industry, exceeding US $100 million. It is also reported to cause opportunistic …

Neutrophils are a critical component of human innate host defense and efficiently kill the
vast majority of invading microorganisms. However, bacterial pathogens such as group A …

Streptococcus pyogenes is an important human pathogen, which has recently gained
recognition as an intracellular microorganism during the course of severe invasive infections …

Streptococcus iniae causes meningoencephalitis and death in cultured fish species and soft-
tissue infection in humans. We recently reported that S. iniae is responsible for local tissue …

Streptococcal species are a diverse group of bacteria which can be found in animals and
humans. Their interactions with host organisms can vary from commensal to pathogenic …