Regulation of virulence factor expression in group A Streptococcus organelles is a
prerequisite to reconstructing the ancient events that have produced today's complex …

Summary Group A Streptococcus (GAS) is a human-specific pathogen that evades the host
immune response through the elaboration of multiple virulence factors. Although many of …

In the last two decades an increasing number of local outbreaks of invasive group A
streptococcus (GAS) infections including necrotizing fasciitis (NF) have been reported. We …

Abstract Background The production of Streptococcus pyogenes exoproteins, many of which
contribute to virulence, is regulated in response to nutrient availability. CodY is a …

CcpA is the global mediator of carbon catabolite repression (CCR) in gram-positive bacteria,
and growing evidence from several pathogens, including the group A streptococcus (GAS) …

Transcription of several key virulence factors of Streptococcus pyogenes is under the control
of Mga and Nra/RofA. In an M serotype 49 (M49) strain, Nra is a negative regulator of pilus …

Streptococcus iniae causes disease in fish and humans and the presence of capsule is
associated with virulence. Tn 917 transposon mutagenesis was performed to identify …

Streptococcus pyogenes (group A streptococcus [GAS]), a multiple-amino-acid-auxotrophic
human pathogen, may face starvation for essential amino acids during various stages of the …

Streptococcus iniae is a Gram-positive bacterium that is reckoned one of the most severe
aquaculture pathogens. It has a broad host range among farmed marine and freshwater fish …

The ability of Streptococcus pyogenes to infect different niches within its human host most
likely relies on its ability to utilize alternative carbon sources. In examining this question, we …