Gold nanoparticles induce tumor vessel normalization and impair metastasis by inhibiting endothelial Smad2/3 signaling

N Huang, Y Liu, Y Fang, S Zheng, J Wu, M Wang… - ACS …, 2020 - ACS Publications
Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery
properties and inherent anti-neoplastic activity. Here, we focused on the anti-neoplastic …

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition

W Li, X Li, S Liu, W Yang, F Pan, XY Yang… - International journal …, 2017 - Taylor & Francis
Angiogenesis is a process by which vessels are formed through preexisting ones, and this
plays a key role in the progression of solid tumors. However, tumor vessels are influenced …

Gold nanoparticles induce nanostructural reorganization of VEGFR2 to repress angiogenesis

Y Pan, H Ding, L Qin, X Zhao, J Cai… - Journal of biomedical …, 2013 - ingentaconnect.com
The inhibition of the binding between VEGFs and their receptors reduces angiogenesis and
retards tumor growth. Owing to the large amount of antibodies required, the antibody-based …

Gold Nanoparticles Disrupt Tumor Microenvironment - Endothelial Cell Cross Talk To Inhibit Angiogenic Phenotypes in Vitro

Y Zhang, X Xiong, Y Huai, A Dey… - Bioconjugate …, 2019 - ACS Publications
It is currently recognized that perpetual cross talk among key players in tumor
microenvironment such as cancer cells (CCs), cancer associated fibroblasts (CAFs), and …

Using gold nanoparticles to disrupt the tumor microenvironment: an emerging therapeutic strategy

JR Melamed, RS Riley, DM Valcourt, ES Day - Acs Nano, 2016 - ACS Publications
Gold nanoparticles have received much attention recently as carriers for anticancer drugs
and therapeutic oligonucleotides, but little research has investigated their potential to act as …

[HTML][HTML] Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells

Y Zhang, CK Elechalawar, MN Hossen, ER Francek… - Bioactive materials, 2021 - Elsevier
Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment
(TME) and an important contributor to cancer progression and therapeutic resistance …

Green synthesized apigenin conjugated gold nanoparticles inhibit cholangiocarcinoma cell activity and endothelial cell angiogenesis in vitro

N Ngernyuang, M Wongwattanakul, W Charusirisawad… - Heliyon, 2022 - cell.com
Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor
clinical outcomes due to a lack of effective therapies to improve disease management. The …

Gold nanoparticles inhibit tumor growth via targeting the Warburg effect in a c-Myc-dependent way

L Sun, Y Liu, N Yang, X Ye, Z Liu, J Wu, M Zhou… - Acta Biomaterialia, 2023 - Elsevier
Gold nanoparticles (AuNPs) are prospective tools for nano-based medicine that can directly
target cellular biological processes to influence cell fate and function. Studies have revealed …

Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels

X Zhao, J Pan, W Li, W Yang, L Qin… - International journal of …, 2018 - Taylor & Francis
Background Tumor vessels were persistently compressed by solid stress from tumor
interstitial matrix, resulting in limited vessel perfusion and oxygen concentrations. Collagen …

Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent …

SR Satapathy, A Nayak, S Siddharth, S Das… - … , Biology and Medicine, 2018 - Elsevier
Complete eradication of aggressive oral cancer remains a challenge due to the presence of
CSCs. They resist conventional chemotherapeutic agents due to their self-renewal, drug …