Two forms of arginase, both catalyzing the hydrolysis of arginine to ornithine and urea, are
found in animals ranging from amphibians to mammals. In humans, inherited deficiency of …

A full-length cDNA encoding type II arginase was isolated from a human kidney cDNA library
and its sequence compared to those of vertebrate type I arginases as well as to arginases of …

There are two forms of arginase in humans, both catalyzing the hydrolysis of arginine to
ornithine and urea. Recent studies in animal models and in Type I arginase-deficient …

Deficiency of liver arginase (AI) causes hyperargininemia (OMIM 207800), a disorder
characterized by progressive mental impairment, growth retardation, and spasticity and …

A human liver cDNA library was screened by colony hybridization with a rat liver arginase
cDNA. The number of positive clones detected was in agreement with the estimated …

Mammals express two isoforms of arginase, designated types I and II. Arginase I is a
component of the urea cycle, and inherited defects in arginase I have deleterious …

Knockout mouse models have been created to study the consequences of deficiencies in
arginase AI and AII, both individually and combined. The AI knockout animals die by 14 days …

Liver-type arginase (arginase I) is expressed almost exclusively in the liver and catalyzes
the last step of urea synthesis, whereas the nonhepatic type (arginase II) is expressed in …

Mammals contain two genes encoding distinct isoforms of arginase (arginases I and II), both
of which catalyze the conversion of arginine to ornithine and urea. However, their …

The urea cycle is a series of six reactions necessary to rid the body of the nitrogen
generated by the metabolism, primarily of amino acids, from the diet or released as the result …