Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …

While adipose tissue-associated macrophages contribute to development of chronic
inflammation and insulin resistance of obesity, little is known about the role of hepatic …

Recruited adipose tissue macrophages contribute to chronic and low-grade inflammation
causing insulin resistance in obesity. Similarly, we hypothesized here that Kupffer cells, the …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

The polarization of adipose tissue-resident macrophages toward the alternatively activated,
anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the …

Obesity is associated with infiltration of macrophages into adipose tissue. Adipose
macrophages may contribute to an elevated inflammatory status by secreting a variety of …

Chronic inflammation is now recognized as a key step in the pathogenesis of obesity-
induced insulin resistance and type 2 diabetes mellitus. This low-grade inflammation is …

OBJECTIVE Increased activity of the innate immune system has been implicated in the
pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 …

Obesity promotes insulin resistance associated with liver inflammation, elevated glucose
production, and type 2 diabetes. Although insulin resistance is attenuated in genetic mouse …

Obesity is causally linked to a chronic state of “low-grade” inflammation in adipose tissue.
Prolonged, unremitting inflammation in this tissue has a direct impact on insulin-sensitive …