Immunoregulation of bone marrow‐derived mesenchymal stem cells on the chronic cigarette smoking‐induced lung inflammation in rats

X Li, J Wang, J Cao, L Ma, J Xu - BioMed Research …, 2015 - Wiley Online Library
Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking‐induced
lung inflammation is poorly understood. In this study, a rat model of smoking‐related lung …

TNF‐α‐induced NF‐κB activation promotes myofibroblast differentiation of LR‐MSCs and exacerbates bleomycin‐induced pulmonary fibrosis

J Hou, T Ma, H Cao, Y Chen, C Wang… - Journal of cellular …, 2018 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease of
unknown cause. It has been reported that both lung resident mesenchymal stem cells (LR …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow

M Ricciardi, G Malpeli, F Bifari, G Bassi, L Pacelli… - PLoS …, 2012 - journals.plos.org
Mesenchymal stromal cells (MSCs) reside in many organs including lung, as shown by their
isolation from fetal lung tissues, bronchial stromal compartment, bronchial-alveolar lavage …

Lung fibrosis is improved by extracellular vesicles from IFNγ-primed mesenchymal stromal cells in murine systemic sclerosis

P Rozier, M Maumus, ATJ Maria, K Toupet… - Cells, 2021 - mdpi.com
Background: Systemic sclerosis (SSc) is a severe autoimmune disease for which
mesenchymal stromal cells (MSCs)-based therapy was reported to reduce SSc-related …

Transcriptional profiling of circulating mononuclear cells from patients with chronic obstructive pulmonary disease receiving mesenchymal stromal cell infusions

JD Armitage, DBA Tan, M Sturm… - Stem Cells …, 2021 - academic.oup.com
Chronic obstructive pulmonary disease (COPD) is an inflammatory airways disease with
limited therapeutic options. We have previously shown that mesenchymal stromal cell (MSC) …

Interpreting immunoregulation in lung fibrosis: a new branch of the immune model

F Huaux - Frontiers in Immunology, 2021 - frontiersin.org
Immunostimulation is recognized as an important contribution in lung fibrosis in some
animal models and patient subsets. With this review, we illustrate an additional scenario …

Current therapeutic strategies for respiratory diseases using mesenchymal stem cells

M Wang, T Zhou, Z Zhang, H Liu, Z Zheng, H Xie - MedComm, 2021 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) have a great potential to proliferate, undergo multi‐
directional differentiation, and exert immunoregulatory effects. There is already much …

Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis

IE Fernandez, FR Greiffo… - European …, 2016 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung
function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated …

Human umbilical cord mesenchymal stromal cells attenuate pulmonary fibrosis via regulatory T cell through interaction with macrophage

Z Tang, J Gao, J Wu, G Zeng, Y Liao, Z Song… - Stem Cell Research & …, 2021 - Springer
Background Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic
options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy is being …