The aggregation propensity of each particular protein seems to be shaped by evolution
according to its natural abundance in the cell. The production and downstream processing …

Protein aggregation is responsible for the onset and spread of many human diseases,
ranging from neurodegenerative disorders to cancer and diabetes. Moreover, it is one of the …

Protein aggregation is a hallmark of a growing number of human disorders and constitutes a
major bottleneck in the manufacturing of therapeutic proteins. Therefore, there is a strong …

Abstract Summary Aggrescan3D (A3D) standalone is a multiplatform Python package for
structure-based prediction of protein aggregation properties and rational design of protein …

Introduction: The rapid development of protein therapeutics is providing life-saving therapies
for a wide range of human diseases. However, degradation reactions limit the quality and …

Protein aggregation underlies the development of an increasing number of conformational
human diseases of growing incidence, such as Alzheimer's and Parkinson's diseases …

Protein aggregation is behind the genesis of incurable diseases and imposes constraints on
drug discovery and the industrial production and formulation of proteins. Over the years, we …

The solubility of globular proteins is a basic biophysical property that is usually a
prerequisite for their functioning. In this study, we probed the solubility of globular proteins …

Protein aggregation is a widespread phenomenon that stems from the establishment of non-
native intermolecular contacts resulting in protein precipitation. Despite its deleterious …

Protein aggregation is a major factor limiting the biotechnological and therapeutic
application of many proteins, including enzymes and monoclonal antibodies. The molecular …