Risk factors for intracranial haemorrhage in patients with pulmonary embolism treated with thrombolytic therapy Development of the PE-CH Score

S Chatterjee, I Weinberg, RW Yeh… - Thrombosis and …, 2017 - thieme-connect.com
Pulmonary embolism (PE) is a major cause of morbidity and mortality world-wide, and the
use of thrombolytic therapy has been associated with favourable clinical outcomes in certain …

Thrombolytic therapy for pulmonary embolism: frequency of intracranial hemorrhage and associated risk factors

DS Kanter, KM Mikkola, SR Patel, JA Parker… - Chest, 1997 - Elsevier
Study objectives To determine the risk factors and frequency of intracranial hemorrhage
among patients undergoing thrombolysis for pulmonary embolism. Design A retrospective …

Intracerebral hemorrhage with thrombolytic therapy for acute pulmonary embolism

PD Stein, F Matta, DS Steinberger, DC Keyes - The American journal of …, 2012 - Elsevier
BACKGROUND: Intracranial hemorrhage is one of the dreaded complications of
thrombolytic therapy for acute pulmonary embolism. We identified patients with pulmonary …

Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis

S Chatterjee, A Chakraborty, I Weinberg, M Kadakia… - Jama, 2014 - jamanetwork.com
Importance Thrombolytic therapy may be beneficial in the treatment of some patients with
pulmonary embolism. To date, no analysis has had adequate statistical power to determine …

Transforming and simplifying the treatment of pulmonary embolism:“safe dose” thrombolysis plus new oral anticoagulants

M Sharifi, Z Vajo, W Freeman, C Bay, M Sharifi… - Lung, 2015 - Springer
Background Administration of systemic thrombolysis in pulmonary embolism (PE) has been
limited to severe forms due to the risk of intracerebral hemorrhage (ICH). There is growing …

Derivation and validation of a clinical prediction rule for thrombolysis-associated major bleeding in patients with acute pulmonary embolism: the BACS score

L Jara-Palomares, D Jiménez, B Bikdeli… - European …, 2020 - Eur Respiratory Soc
Background Improved prediction of the risk of major bleeding in patients with acute
pulmonary embolism (PE) receiving systemic thrombolysis is crucial to guide the choice of …

Bleeding risk with systemic thrombolytic therapy for pulmonary embolism: scope of the problem

MJ Daley, MS Murthy… - Therapeutic advances in …, 2015 - journals.sagepub.com
Acute pulmonary embolism represents a major complication of venous thromboembolism
that is associated with high morbidity and mortality. Guidelines recommend the rapid …

Understanding haemorrhagic risk following thrombolytic therapy in patients with intermediate-risk and high-risk pulmonary embolism: a hypothesis paper

P Abraham, DA Arroyo, R Giraud, H Bounameaux… - Open …, 2018 - openheart.bmj.com
While systemic intravenous thrombolysis decreases mortality in patients with high-risk
pulmonary embolism (PE), it clearly increases haemorrhagic risk. There are many …

Pulmonary embolism: whom to discharge and whom to thrombolyze?

G Meyer, B Planquette… - Journal of Thrombosis and …, 2015 - Wiley Online Library
Patients with pulmonary embolism can be divided in two groups according to their risk of
death or major complication: a small group of high‐risk patients defined by the presence of …

Thrombolysis for acute intermediate-risk pulmonary embolism: a meta-analysis

G Gao, P Yang, M Liu, M Ding, G Liu, Y Tong… - Thrombosis …, 2015 - Elsevier
Background The use of thrombolytic therapy in patients with intermediate-risk pulmonary
embolism is controversial. To compare with anticoagulation alone, no analysis before has …