The enzyme myo-inositol monophosphatase plays a key role in controlling the
phosphoinositide (PI) secondary messenger system'. Uncompetitive inhibition of this …

Inhibitors of myo-lnositol Monophosphatase containing Methylenebisphosphonic Acid as a
Replacement for a Phosphate Group Page 1 J. CHEM. SOC., CHEM. COMMUN., 1991 …

α-Hydroxyphosphonates are moderately potent (Ki= 6–600μM) inhibitors of the enzyme myo-
inositol monophosphatase (McLeod et al., Med. Chem. Res. 1992, 2, 96). Hydroxy-[4-(5, 6 …

The phosphate group in the inositol-1-phosphatase inhibitor (1) is replaced by less polar
phosphorus containing groups (substituted phosphate and phosphonates), by sulphur …

The 3, 5, 6-trisdeoxy derivative of myo-Inositol 1-monophosphate,(1S)-phosphoryloxy-(2R,
4S)-dihydroxycyclohexane [(–)-(1)], derived from the parent substrate by a strategy of …

Revised Manuscript Received June 24, 1994® abstract: The interactions of synthetic
analogues of D-myo-inositol 1, 4, 5-trisphosphate [Ins (l, 4, 5) P3] with the Ins (l, 4, 5) P3 …

From a series of 4-hydroxyphenoxymethylene bisphosphonic acid derivatives 1-(4-
Hydroxyphenoxy)-1-(methyl) methylenebisphosphonic acid has been identified as a …

myo-Inositol monophosphatase (IMPase), the proposed target for lithium therapy for manic
depression, is an important enzyme in the biosynthesis of second messengers. Earlier …

Arylalkylmonofluorophosphonates were prepared by condensation of arylalkylaldehydes
with the lithium salt of diethyl 1-fluoro-1-(trimethylsilyl)-methylphosphonate. Reduction and …

myo-Inositol monophosphatase is inhibited by the arginine-specific reagent phenylglyoxal.
The rate of inactivation is decreased in the presence of Pi, a competitive inhibitor of the …