Antigenes, which are substances that inhibit gene expression by binding to double‐stranded
DNA (dsDNA) in a sequence‐specific manner, are currently sought for the treatment of …

Novel bicyclo nucleosides, 2′-O, 4′-C-ethylene nucleosides and 2′-O, 4′-C-propylene
nucleosides, were synthesized as building blocks for antisense oligonucleotides to further …

Triplex-forming ability of the oligonucleotides containing one 2′-O, 4′-C-
methyleneribonucleic acid (2′, 4′-BNA) unit was investigated by measurement of the …

For development of ideal antisense and antigene molecules, various chemical modifications
of oligonucleotides have been studied. However, despite their importance, there is only …

Abstract Novel nucleosides, 2′-O, 4′-C-ethylene nucleosides and their corresponding
phosphoramidites, were synthesized as building blocks for antisense oligonucleotides. The …

Novel 2-O, 4-C-ethylene nucleosides have been synthesized as building blocks for
antisense and antigene oligonucleotides. 2-O, 4-C-Ethylene-bridged nucleic acids (ENATM) …

To develop antisense oligonucleotides, novel nucleosides, 2′-O, 4′-C-ethylene
nucleosides and their corresponding phosphoramidites, were synthesized as building …

The triplex-forming abilities of some conformationally restricted nucleotide analogs are
disclosed and compared herein. 2′-Amino-LNA monomers proved to be less stabilising to …

Oligodeoxynucleotides with spermine conjugation at C4 of 5-Me-dC (sp-ODN) exhibit triple
helix formation with complementary Watson-Crick duplexes, and were optimally stable at …

The formation of triplex DNA is a site-specific recognition method that directly targets duplex
DNA. However, triplex DNA formation is generally formed for the GC and AT base pairs of …