The fidelity of protein transport in the secretory pathway relies on the accurate sorting of
proteins to their correct destinations. To deepen our understanding of the underlying …

Coat protein complex II (COPII) plays an integral role in the packaging of secretory cargoes
within membrane-enclosed transport carriers that leave the endoplasmic reticulum (ER) from …

Estimates based on proteomic analyses indicate that a third of translated proteins in
eukaryotic genomes enter the secretory pathway. After folding and assembly of nascent …

Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the
initial step in protein secretion. COPII‐coated vesicles mediate the export of newly …

The flow of cargo vesicles along the secretory pathway requires concerted action among
various regulators. The COPII complex, assembled by the activated SAR1 GTPases on the …

Membrane trafficking in eukaryotic cells is a highly dynamic process, which needs to adapt
to a variety of cargo proteins. The COPII coat mediates ER export of thousands of proteins …

The vast majority of proteins that are transported to different cellular compartments and
secreted from the cell require coat protein complex II (COPII) for export from the endoplasmic …

Export of cargo from the endoplasmic reticulum (ER) is the first membrane trafficking step in
the secretory pathway. To date, all cargo proteins appear to use a common set of machinery …

Secretory cargo is recognized, concentrated and trafficked from endoplasmic reticulum (ER)
exit sites (ERES) to the Golgi. Cargo export from the ER begins when a series of highly …

Accurate maintenance of organelle identity in the secretory pathway relies on retention and
retrieval of resident proteins. In the endoplasmic reticulum (ER), secretory proteins are …