Background & Aims: 4, 4'-Diethylaminoethoxyhexestrol (DEAEH), amiodarone, and
perhexiline cause steatohepatitis in humans. The mechanisms of these effects are unknown …

Mitochondria are involved in fatty acid β-oxidation, the tricarboxylic acid cycle, and oxidative
phosphorylation, which provide most of the cell energy. Mitochondria are also the main …

In an attempt to better understand the mechanisms for pseudoalcoholic liver lesions in
human beings, we determined the effects of perhexiline on mitochondrial functions in mice …

Mitochondrial dysfunction is a major mechanism of liver injury. A parent drug or its reactive
metabolite can trigger outer mitochondrial membrane permeabilization or rupture due to …

Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial …

Microvesicular steatosis occurs in conditions characterized by severe impairment of the
mitochondrial β-oxidation process, due to genetic and/or acquired causes. Drugs and some …

Non-alcoholic steatohepatitis (NASH) is an increasing recognized condition that may
progress to end-stage liver disease. There are consistent evidences that mitochondrial …

Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and
other serious side effects such as lactic acidosis and rhabdomyolysis in some patients. By …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Impairment of liver mitochondrial β-oxidation is an important mechanism of drug-induced
liver injury. Four inhibitors of fatty acid oxidation were compared in short-term rat in vivo …